As mentioned above, on Persona 4there is Kanji, the tallest member of the Investigation Team, and Nao tothe shortest. With his Badass Longcoat on, you'd probably never notice most of them if they're standing behind him. Well before these Johnny-come-latelies, the original dimorphic superhero couple: A nonromantic example from Tales of Symphonia: Life on the Street had Emma Zoole.
Narumi and Shirogane of Karakuri Circus ; while Shirogane is pretty average, Narumi is an enormous kempoist.
Huge Guy, Tiny Girl
From Wikimedia Commons, the free media repository. He takes the name Ziggy and starts to reconsider his request to have his human memories destroyed. Night Lion and Lotus Lynx. Ken Follet's The Pillars of the Earth: Obviously different authors said differently, but the Thing never got a "giant penis" joke, while other "big guys" like the Hulkhad. Even if Poison is a transwoman, she still counts. And then there's Ted Buckland and his girlfriend, 'The Gooch'.